TissueView&trade

A contact ATR spectrum is collected from human skin.

Remspecís fiber-optic technology is ideal for non-invasive analysis of soft tissue.

Contact ATR spectra are obtained by pressing an ATR crystal firmly against the target tissue, giving the mid-IR spectrum of the surface layer to a depth of a few microns. Changes due to tissue degradation, or following treatment with lotions etc., can be characterized rapidly.

A flat-tipped ATR crystal is used for contact ATR of soft tissue to allow for good optical contact with minimal tissue damage.

Typical mid-IR spectra of soft tissue include characteristic "amide I" and "amide II" bands between 1700 and 1600 cm-1; these features originate from proteins.

TissueView spectra of human skin (navy trace) and human cartilage (red trace)

Selected References

A chemometric analysis for evaluation of early-stage cartilage degradation by infrared fiber-optic probe spectroscopy, G Li,M Thomson,E Dicarlo,X Yang,B Nestor,MP Bostrom,NP Camacho, Appl Spectrosc. 2005 Dec;59(12):1527-33.


Attenuated Total Reflection Fourier Transform Infrared
Spectroscopy as a Possible Method to Investigate Biophysical
Parameters of Stratum Corneum In Vivo
, L Brancaleon, M P Bamberg, T Sakamaki, and N Kollias, J. Investigative Dermatology,116 ( 3), 2001, 380-386